Sucrose Octasulfate Potassium Salt

Description

Sucrose Octasulfate Potassium Salt is a highly purified, multi-sulfated oligosaccharide compound designed for advanced pharmaceutical formulation applications. It is manufactured under strict quality control systems to ensure low endotoxin levels and compliance with major pharmacopoeia standards, including USP and Chinese Pharmacopoeia (ChP).

This material is registered with NMPA CDE (No. F20210000349) and is currently under US FDA DMF submission (No. 036552), supporting its suitability for global pharmaceutical development and regulatory applications.

Product Identification

• Chemical Name: Sucrose Octasulfate Potassium Salt

• CAS Number: 73264-44-5

• Molecular Formula: C₁₂H₁₄K₈O₃₅S₈

• Quality Grade: Injection / Pharmaceutical grade

• Regulatory Status: NMPA CDE F20210000349, US DMF 036552 (in preparation)

• Purity: High purity, low endotoxin profile

• Impurity Control: Potassium sucrose heptasulfate < 0.1%

• Packaging: 1 kg / customized packaging available

• Shelf Life: 24 months under recommended storage conditions

Functional Role in Pharmaceutical Applications

Sucrose Octasulfate Potassium Salt is increasingly recognized as a multifunctional excipient in modern drug delivery systems. It is particularly valuable in advanced formulation technologies such as liposomal and nanoparticle-based drug carriers.

In liposome systems, it can act as a functional loading enhancer, helping to improve drug encapsulation efficiency and maintain structural integrity during preparation and storage. It is especially useful in stabilizing sensitive compounds, including lactone-containing anticancer agents, by reducing hydrolytic degradation and supporting sustained release performance.

Application Advantages

1. Advanced Drug Delivery Systems

• Enhances drug loading capacity in liposomal formulations

• Improves stability of encapsulated active pharmaceutical ingredients

• Supports controlled and sustained release profiles

2. Oncology Formulation Support

• Helps maintain stability of lactone-ring drugs such as irinotecan

• Reduces premature hydrolysis and degradation

• Contributes to extended circulation half-life in delivery systems

3. Dermatology & Tissue Repair Research

• Supports moisture balance and epithelial protection in topical systems

• Assists in reducing microbial adhesion in formulation studies

• Used in research related to wound healing and tissue recovery

4. Dental & Mucosal Applications

• Suitable for topical formulations targeting oral and dental tissues

• Investigated for protective effects on soft tissue environments

Product Characteristics

• Pharmaceutical-grade excipient suitable for injectable formulations

• Consistent batch-to-batch quality control

• Ultra-low endotoxin level for sensitive applications

• Strong compatibility with liposomal and colloidal systems

• Stable under recommended storage conditions (avoid strong acids, alkalis, and oxidizing agents)

Storage Conditions

Store in a sealed container in a cool, dry environment. Avoid exposure to extreme pH conditions and oxidizing substances to maintain product stability.

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